The Sherpa phenomenon and human evolution
The "Sherpa Phenomenon": Human Evolution at Work
Scientists have long wondered why the sherpas of the Tibetan Highlands can negotiate with ease elevations that cause some humans to become life-threateningly ill. Tibetans live at altitudes of 13,000 feet, breathing air that has 40 percent less oxygen than is available at sea level, yet suffer very little mountain sickness. The reason, according to a team of biologists in China, is human evolution, in what may be the most recent and fastest instance detected so far.
Comparing the genomes of Tibetans and Han Chinese, the majority ethnic group in China, the biologists found that at least 30 genes had undergone evolutionary change in the Tibetans as they adapted to life on the high plateau. Tibetans and Han Chinese split apart as recently as 3,000 years ago, say the biologists, a group at the Beijing Genomics Institute led by Xin Yi and Jian Wang, according to recent reports in Science and the New York Times.
Elsewhere, researchers from the University of Utah School of Medicine and Qinghai University Medical School in the People's Republic of China found that thousands of years ago, Tibetan highlanders began to genetically adapt to prevent polycythemia (a process in which the body produces too many red blood cells in response to oxygen deprivation), as well as other health abnormalities such as swelling of the lungs and brain (edema) and hypertension of the lung vessels leading to eventual respiratory failure.
Even at elevations of 14,000 feet above sea level or higher, where the atmosphere contains much less oxygen than at sea level, most Tibetans do not overproduce red blood cells and do not develop lung or brain complications.
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